Global evidence on molecular adsorbent recirculating system uses for trauma-induced acute liver failure: A scoping review

Table 2 Clinical and laboratory outcomes of molecular adsorbent recirculating system therapy in trauma-associated acute liver dysfunction

Ref.	Primary outcomes	Secondary outcomes	Adverse events
Ben-Abraham et al[3]; 2003	Survival 100% (1/1), liver recovery (1/1)	Normalized intracranial pressure, improved bilirubin, ammonia, international normalized ratio, factor V	Not reported
Rittler et al[4]; 2004	Mortality 100% (5/5)	Reduced bilirubin; no improvement in ammonia, coagulopathy	Bleeding, thrombocytopenia
Monet et al[14]; 2022	Survival 40%, transplantation-free (acute liver failure, 13/32); variable by group	Improved bilirubin, prothrombin time, hepatic encephalopathy, pruritus	Thrombocytopenia (30.6%), hypotension, hypothermia
Powell et al[5]; 2024	Survival 50% (4/8 trauma cases)	Improved aspartate aminotransferase, alanine aminotransferase, international normalized ratio, lactic acid; no change in ammonia; no improvement in hepatic encephalopathy	Not reported