©Author(s) (or their employer(s)) 2026.
World J Crit Care Med. Mar 9, 2026; 15(1): 114318
Published online Mar 9, 2026. doi: 10.5492/wjccm.v15.i1.114318
Published online Mar 9, 2026. doi: 10.5492/wjccm.v15.i1.114318
Table 1 Univariate Analysis of Baseline Characteristics in Septic Shock Patients with and without acute kidney injury, mean (95%CI)
| Variables | Without AKI (n = 5108) | With AKI (n = 6552) | P value |
| Age (years) | 67 (55-79) | 69 (58-79) | < 0.001 |
| Body mass index (kg/m2) | 26.3 (22.3-31.6) | 27.3 (23.0-33.2) | < 0.001 |
| Sequential Organ Failure Assessment on admission | 6 (4-9) | 7 (5-10) | < 0.001 |
| White blood counts (× 103 cells/L) | 13.0 (8.6-18.4) | 14.0 (9.4-19.7) | < 0.001 |
| Platelet count (× 103 cells/L) | 220 (156-298) | 211 (149-294) | < 0.001 |
| Lymphocyte count (× 103 cells/L) | 962 (557-1578) | 930 (534-1560) | 0.023 |
| Neutrophil count (× 103 cells/L) | 10.3 (6.3-15.1) | 11.3 (7.0-16.4) | < 0.001 |
| Monocytes (× 103 cells/L) | 7.4 (4.1-11.5) | 7.7 (4.3-12.1) | 0.003 |
| Neutrophil-to-lymphocyte ratio | 10.1 (5.2-18.2) | 11.4 (6.1-22.0) | < 0.001 |
| Platelet-to-lymphocyte ratio | 226 (132-378) | 222 (130-391) | 0.949 |
| Monocyte-to-lymphocyte ratio | 0.7 (0.4-1.2) | 0.8 (0.4-1.3) | < 0.001 |
| Sodium (mmol/L) | 136 (133-139) | 136 (132-140) | 0.008 |
| Potassium (mmol/L) | 4.0 (3.7-4.5) | 4.2 (3.7-4.8) | < 0.001 |
| Magnesium (mg/dL) | 1.8 (1.5-2.0) | 1.8 (1.5-2.1) | < 0.001 |
| Albumin (g/dL) | 3.1 (2.6-3.6) | 3.1 (2.6-3.6) | < 0.001 |
| Initial lactate (mmol/L) | 2.1 (1.3-3.4) | 2.4 (1.5-3.9) | < 0.001 |
| Initial international normalized ratio | 1.2 (1.1-1.5) | 1.3 (1.1-1.6) | < 0.001 |
| Initial alanine aminotransferase (U/L) | 25 (22-28) | 25 (16-45) | 0.751 |
| Initial aspartate aminotransferase (U/L) | 29 (19-51) | 30 (20-57) | < 0.001 |
| Bicarbonate (mmol/L) | 25 (22-28) | 23 (20-27) | < 0.001 |
| Chloride (mmol/L) | 101 (97-104) | 100 (96-105) | < 0.001 |
| Blood urea nitrogen (mg/dL) | 20 (14-31) | 34 (22-53) | < 0.001 |
| Lactate-albumin ratio | 0.7 (0.4-1.1) | 0.8 (0.5-1.4) | < 0.001 |
| Creatinine (mg/dL) | 0.91 (0.70-1.30) | 1.8 (1.2-3.0) | < 0.001 |
| Total bilirubin (mg/dL) | 0.6 (0.4-1.1) | 0.7 (0.4-1.2) | 0.004 |
| Hemoglobin (g/dL) | 11.9 (10.0-13.5) | 11.5 (9.8-13.2) | < 0.001 |
| Systemic immune-inflammation index | 2185 (995-4393) | 2413 (1131-4838) | < 0.001 |
| Neutrophil-percentage-to-albumin ratio | 25.5 (21.1-31.3) | 26.0 (21.8-32.2) | < 0.001 |
| Systemic inflammation response index | 7072 (2760-15160) | 8216 (3390-18048) | < 0.001 |
| Aggregate index of systemic inflammation (× 109/L) | 1.53 (0.50-3.83) | 1.72 (0.59-4.32) | < 0.001 |
- Citation: Rajendran J, Ang SP, Lorenzo-Capps MJ, Valladares C, Lee E, Bommu VJL, Altarcha G, Pominov S, Gregory B, Chia JE, Iglesias J. Predicting acute kidney injury in septic shock patients using inflammatory indices in the intensive care unit. World J Crit Care Med 2026; 15(1): 114318
- URL: https://www.wjgnet.com/2220-3141/full/v15/i1/114318.htm
- DOI: https://dx.doi.org/10.5492/wjccm.v15.i1.114318