©Author(s) (or their employer(s)) 2026.
World J Crit Care Med. Mar 9, 2026; 15(1): 114225
Published online Mar 9, 2026. doi: 10.5492/wjccm.v15.i1.114225
Published online Mar 9, 2026. doi: 10.5492/wjccm.v15.i1.114225
Table 1 Summary of studies on the diagnostic role of microRNAs in sepsis and septic shock
| Ref. | Year | Study type | Up/downregulated | Area under the curve | MicroRNAs | Diagnostic purpose | Sample size |
| García-Concejo et al[14] | 2025 | Prospective multicenter observational study | Down | 0.960 (validation) | MiR-451a, miR-100-5p, miR-148a-3p | Differentiating septic shock from non-septic shock | 161 (109 discovery, 52 validation) |
| Ye et al[15] | 2025 | Prospective observational cohort study | Up | 0.825 (sepsis), 0.821 (septic shock) | MiR-9-5p | Predicting sepsis and septic shock | 134 (69 sepsis, 30 non-sepsis, 35 healthy) |
| Li et al[13] | 2025 | Prospective observational study | Down | 13.17 | MiR-193b-5p | Distinguishing sepsis from healthy conditions | 105 (15 exploratory, 90 validation) |
| Behroozizad et al[16] | 2024 | Case-control study | Up | 1.25 | MiR-135a | Independent predictor of sepsis | 200 (100 sepsis, 100 healthy) |
| Li et al[17] | 2025 | Case-control study | Up | 14.39 | MiR-181a-5p | Biomarker for sepsis | 244 (119 sepsis, 125 healthy) |
- Citation: Fraioli V, Sanvitti M, Bilotta F. MicroRNAs in sepsis: Advances in diagnosis and prognostic monitoring. World J Crit Care Med 2026; 15(1): 114225
- URL: https://www.wjgnet.com/2220-3141/full/v15/i1/114225.htm
- DOI: https://dx.doi.org/10.5492/wjccm.v15.i1.114225