Use of radiograph scoring systems to assess pulmonary disease severity in patients with COVID-19 pneumonia

Table 2 Performance of BRIXIA and Radiographic Assessment of Lung Edema scores for predicting oxygen delivery device and discharge outcomes in the emergency department and during hospitalization

BRIXIA score	Cut-off point (95%CI)	Sensitivity	Specificity	AUC at cut-point (95%CI)
Oxygen delivery device in ED
Room air	7 (6-8)	0.43	0.39	0.41 (0.38-0.44)
Nasal cannula	8 (7-9)	0.51	0.60	0.56 (0.52-0.59)
Hudson mask	9 (6-12)	0.36	0.61	0.49 (0.38-0.59)
NRBM	9 (8-10)	0.66	0.64	0.65 (0.60-0.70)
HFNC/CPAP/BiPAP	12 (9-15)	0.65	0.84	0.74 (0.64-0.85)
Oxygen delivery device during hospitalization
Nasal cannula	6 (4-8)	0.60	0.48	0.54 (0.47-0.61)
Hudson mask	13 (6-20)	0.29	0.86	0.57 (0.42-0.72)
NRBM	8 (7-9)	0.58	0.66	0.62 (0.59-0.65)
HFNC/CPAP/BiPAP	8 (7-9)	0.63	0.61	0.62 (0.58-0.66)
Oral intubation/tracheostomy	8 (6-10)	0.65	0.60	0.63 (0.58-0.67)
RALE score
Oxygen delivery device in ED
Room air	12 (8-16)	0.49	0.57	0.42 (0.39-0.45)
Nasal cannula	10 (7-13)	0.58	0.57	0.54 (0.51-0.57)
Hudson mask	14 (8-20)	0.41	0.61	0.54 (0.43-0.64)
NRBM	16 (10-22)	0.54	0.72	0.62 (0.57-0.68)
HFNC/CPAP/BiPAP	17 (12-22)	0.65	0.77	0.74 (0.65-0.83)
Oxygen delivery device during hospitalization
Nasal cannula	12 (6-18)	0.29	0.85	0.52 (0.46-0.59)
Hudson mask	13 (0-29)	0.58	0.65	0.55 (0.42-0.69)
NRBM	13 (10-16)	0.64	0.61	0.6 (0.57-0.63)
HFNC/CPAP/BiPAP	16 (11-21)	0.66	0.59	0.59 (0.55-0.64)
Oral intubation/tracheostomy	16 (12-20)	0.52	0.36	0.62 (0.57-0.66)

AUC: Area under the curve; CI: Confidence interval; ED: Emergency department; NRBM: Non-rebreather mask; HFNC: High flow nasal cannula; CPAP: Continuous positive airway pressure; BiPAP: Bi-level positive airway pressure; RALE: Radiographic Assessment of Lung Edema.