Death in patients with immune-mediated inflammatory diseases in the intensive care unit: First week data

Table 4 Predictors of lethal outcome (data on the fifth day of staying in the intensive care unit), median (interquartile range)

Predictor	Se	Sp	OR (95%CI)	RR (95%CI)	Р value
Maximum HR > 97 per minute	91.7	18.5	2.5 (0.3-24.1)	2.0 (0.3-12.8)	0.039
CRP > 28 mg/L	88.9	85.7	48.0 (4.3-535.3)	13.8 (2.0-96.3)	0.0001
Triglycerides > 2.3 mmol/L	100.0	63.6	-	-	0.029
Creatinine > 58 μmol/L	80.0	69.6	9.1 (1.5-54.5)	4.8 (1.2-19.3)	0.009
Fibrinogen > 3.3 g/L	80.0	95.5	84.0 (6.7-1060)	10.2 (2.7-39.2)	0.00001
Glasgow coma scale score ≤ 14 points	90.0	69.6	20.6 (2.2-195.0)	9.6 (1.4-67.2)	0.002
SOFA > 2 points	100.0	70.0	-	-	0.0003
Need in MV	54.5	91.3	12.6 (1.9-82.1)	3.9 (1.6-9.4)	0.002
Need in vasopressors	27.3	95.7	7.9 (0.7-91.3)	2.8 (1.2-6.4)	0.038
Compliance with the MAS criteria EULAR/ACR/PRINTO 2016	55.6	86.4	7.9 (1.3-47.5)	3.6 (1.3-10.2)	0.015
No anticoagulant therapy	82.6	72.7	12.7 (2.3-70.0)	2.6 (1.1-5.9)	0.002
Blood transfusion	36.4	95.7	12.6 (1.2-131.9)	2.9 (1.4-6.4)	0.009
Transfusion of FFP	36.4	87.0	3.8 (0.7-21.4)	2.2 (0.9-5.5)	0.021

Se: Sensitivity; Sp: Specificity; CI: Confidence interval; OR: Odds ratio; RR: Respiratory rate; HR: Heart rate; CRP: C-reactive protein; SOFA: Sequential Organ Failure Assessment; MV: Mechanical ventilation; MAS: Macrophage activation syndrome; EULAR: European League Against Rheumatism; ACR: American College of Rheumatology; PRINTO: Paediatric Rheumatology International Trials Organisation; FFP: Fresh frozen plasma.