Death in patients with immune-mediated inflammatory diseases in the intensive care unit: First week data

Table 2 Predictors of lethal outcome (data on the first day of stay in the intensive care unit), median (interquartile range)

Predictor	Se	Sp	OR (95%CI)	RR (95%CI)	P value
Diuresis ≤ 1.5 mL/kg/hour	91.7	61.8	17.8 (2.1-154.2)	2.1 (1.5-3.8)	0.002
Water balance ≤ 74%	100.0	55.9	-	-	0.001
Saturation without oxygen support ≤ 92%	90.9	58.1	15.8 (13.8-139)	2.4 (1.5-3.8)	0.003
Leukocytes ≤ 3.1 × 109/L	50.0	100.0	-	-	0.000004
Platelets ≤ 168 × 109/L	100.0	59.5	-	-	0.0003
Potassium > 4.7 mmol/L	66.7	91.4	15.5 (3.2-75.9)	5.8 (2.1-15.9)	0.0002
Albumin ≤ 30 g/L	90.9	54.3	12.5 (1.4-108.2)	2.1 (1.4-3.1)	0.007
Creatinine > 74 μmol/L	75.0	65.7	5.1 (1.2-22.2)	2.0 (1.2-3.5)	0.023
pH ≤ 7.36	58.3	85.3	8.2 (1.8-36.0)	4.0 (1.6-10.2)	0.003
HCO3- ≤ 22.2	90.0	61.5	14.4 (10.6-131.5)	2.3 (1.4-4.0)	0.006
Glasgow Coma Scale ≤ 13 points	58.3	77.8	4.9 (1.2-19.7)	2.6 (1.5-5.7)	0.019
SOFA > 2 points	100.0	51.5	-	-	0.002
MV-RR > 20 per minute	80.0	83.3	20 (0.9-429.9)	4.8 (0.8-30.3)	0.036
Oxygen therapy via face mask	81.8	78.6	1.9 (1.2-3.1)	6.2 (1.2-32.6)	0.020
Need for mechanical ventilation	41.7	86.8	4.7 (1.1-20.8)	3.2 (1.1-9.1)	0.032
Treatment with bDMARD	15.4	100.0	-	-	0.015
Transfusion of FFP	50.0	83.3	5.0 (1.2-20.9)	3.0 (1.2-7.6)	0.021

Se: Sensitivity; Sp: Specificity; CI: Confidence interval; OR: Odds ratio; RR: Respiratory rate; SOFA: Sequential Organ Failure Assessment; MV: Mechanical ventilation; bDMAD: Biological disease-modifying antirheumatic drugs; FFP: Fresh frozen plasma.