Sedation and analgesia strategies in the neuro intensive care unit

Figure 1 Schematic of the molecular mechanism showing the primary targets of opioid agonists[41]. AC: Adenylate cyclase; cAMP: Cyclic adenosine monophosphate; GDP: Guanosine diphosphate; Glu: Glutamate; GTP: Guanosine-5′-triphosphate; PKA: Protein kinase A. Citation: Marcianò G, Vocca C, Evangelista M, Palleria C, Muraca L, Galati C, Monea F, Sportiello L, De Sarro G, Capuano A, Gallelli L. The Pharmacological Treatment of Chronic Pain: From Guidelines to Daily Clinical Practice. Pharmaceutics 2023; 15: 1165 Copyright© The Authors 2023. Published by MDPI, Basel, Switzerland (https://www.mdpi.com/openaccess).