©The Author(s) 2025.
World J Crit Care Med. Dec 9, 2025; 14(4): 111260
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.111260
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.111260
Table 5 Multivariate analysis on demographics and risk factors associated with the use of continuous midazolam infusion
| Predictors | OR | 95%CI (lower limit, upper limit) | P value |
| Age > 65 years | 0.43 | 0.31, 0.59 | < 0.0001 |
| Teaching ICU | 0.31 | 0.23, 0.42 | < 0.0001 |
| CCM primary | 0.11 | 0.08, 0.16 | < 0.0001 |
| Charlson score > 5 | 0.94 | 0.69, 1.29 | 0.7151 |
| SOFA score > 7 | 1.74 | 1.30, 2.33 | 0.0002 |
| Acute respiratory failure | 2.11 | 1.51, 2.94 | < 0.0001 |
| ARDS | 6.95 | 3.82, 12.64 | < 0.0001 |
| Cardiogenic shock | 3.01 | 1.95, 4.64 | < 0.0001 |
| Septic shock | 0.80 | 0.51, 1.25 | 0.3324 |
| Sepsis | 1.22 | 0.79, 1.88 | 0.3714 |
| Hypovolemic shock | 1.05 | 0.52, 2.12 | 0.8912 |
| Unspecified shock | 1.51 | 1.00, 2.28 | 0.0504 |
| Cardiac arrest | 1.38 | 0.94, 2.02 | 0.1034 |
| Pneumonia (bacterial) | 1.56 | 1.14, 2.14 | 0.005 |
| Viral pneumonia | 7.80 | 2.11, 28.80 | 0.0021 |
| COVID PNA | 0.41 | 0.11, 1.49 | 0.1742 |
| Seizure | 1.77 | 0.92, 3.42 | 0.0895 |
| Status epilepticus | 13.17 | 6.56, 26.45 | < 0.0001 |
| Alcohol withdrawal | 2.30 | 1.41, 3.74 | 0.0008 |
- Citation: Nestoiter KG, Feick K, Looney K, Zaccheo M, Wert Y, Franz C. Critical care primary services are associated with reduced midazolam use in the intensive care unit. World J Crit Care Med 2025; 14(4): 111260
- URL: https://www.wjgnet.com/2220-3141/full/v14/i4/111260.htm
- DOI: https://dx.doi.org/10.5492/wjccm.v14.i4.111260