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Observational Study
©The Author(s) 2025.
World J Crit Care Med. Dec 9, 2025; 14(4): 111260
Published online Dec 9, 2025. doi: 10.5492/wjccm.v14.i4.111260
Table 5 Multivariate analysis on demographics and risk factors associated with the use of continuous midazolam infusion
Predictors
OR
95%CI (lower limit, upper limit)
P value
Age > 65 years0.430.31, 0.59< 0.0001
Teaching ICU0.310.23, 0.42< 0.0001
CCM primary0.110.08, 0.16< 0.0001
Charlson score > 50.940.69, 1.290.7151
SOFA score > 71.741.30, 2.330.0002
Acute respiratory failure2.111.51, 2.94< 0.0001
ARDS6.953.82, 12.64< 0.0001
Cardiogenic shock3.011.95, 4.64< 0.0001
Septic shock0.800.51, 1.250.3324
Sepsis1.220.79, 1.880.3714
Hypovolemic shock1.050.52, 2.120.8912
Unspecified shock1.511.00, 2.280.0504
Cardiac arrest1.380.94, 2.020.1034
Pneumonia (bacterial)1.561.14, 2.140.005
Viral pneumonia7.802.11, 28.800.0021
COVID PNA0.410.11, 1.490.1742
Seizure1.770.92, 3.420.0895
Status epilepticus13.176.56, 26.45< 0.0001
Alcohol withdrawal2.301.41, 3.740.0008


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