Optic nerve sheath diameter trajectories and mortality in children with clinically relevant elevated intracranial pressure

Table 5 Linear mixed effects model for dynamic variability in optic nerve sheath diameter within 48 hours of pediatric intensive care unit admission in patients with clinically relevant elevated intracranial pressure (n = 69)

Random effect1	Variance	SD
Intercept	0.048	0.219
Residual	0.047	0.216
Fixed effect	Estimate	SE	95%CI	P value
Baseline ONSD levels	0.841	0.029	0.784-0.898	< 0.001
GCS at discharge	-0.015	0.007	-0.029 to -0.001	0.03
VIS > 30	-0.004	0.059	-0.119 to 0.112	0.94
PELOD-2 score	-0.018	0.006	-0.029 to -0.006	0.002

¹Random effect accounted for approximately 45% from the linear mixed effects model.

GCS: Glasgow Coma Scale; ONSD: Optic nerve sheath diameter; PELOD-2: Pediatric logistic organ dysfunction-2; PICU: Pediatric intensive care unit; VIS: Vasoactive inotropic score.