Efficacy and safety of exosomes from Wharton’s Jelly-derived mesenchymal stem cells in traumatic brain injury

Table 1 Administration schedule

Rounds	Route	Exosomes from Wharton’s Jelly-derived mesenchymal stem cells
Round 1	IT	30 × 109 exosomes in 3 mL
	IM	30 × 109 exosomes in 3 mL
Round 2 (week 2)	IT	30 × 109 exosomes in 3 mL
	IM	30 × 109 exosomes in 3 mL
Round 3 (week 6)	IT	30 × 109 exosomes in 3 mL
	IM	30 × 109 exosomes in 3 mL
Round 4 (week 10)	IT	30 × 109 exosomes in 3 mL
	IM	30 × 109 exosomes in 3 mL
Round 5 (week 14)	IT	30 × 109 exosomes in 3 mL
	IM	30 × 109 exosomes in 3 mL
Round 6 (week 18)	IT	30 × 109 exosomes in 3 mL
	IM	30 × 109 exosomes in 3 mL

IM: Intramuscular; IT: Intrathecally;