Predictors of lethal outcome in patients with immunoinflammatory diseases hospitalized in the intensive care unit

doi:10.5492/wjccm.v14.i3.101890

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World Journal of Critical Care Medicine

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2220-3141

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Crit Care Med. Sep 9, 2025; 14(3): 101890
Published online Sep 9, 2025. doi: 10.5492/wjccm.v14.i3.101890

Table 3 Comparison of patients with immune-mediated diseases with lethal outcomes and survivors

Parameter	Dead (n = 13)	Alive (n = 38)	P value
Sex, males	5 (38.5)	18 (47.4)	0.578
Age, months, median (25%; 75%)	175 (165; 192)	102 (57; 162)	0.031
Nosological groups	-	-	0.028
MIS-C	1 (7.7)	17 (44.7)	0.016
Systemic rheumatic diseases	10 (76.9)	14 (36.8)	0.013
Infections	2 (15.4)	7 (18.4)	0.059
Time to ICU from the hospital admission, days, median (25%; 75%)	30 (13; 100)	7 (6; 18)	0.013
Preceding intensive IST	7 (53.9)	7 (18.4)	0.013
Newly started IST in ICU	5 (38.5)	24 (63.2)	0.121
Follow-up IST	12 (92.3)	31 (81.6)	0.359
Overall glucocorticosteroids	12 (92.3)	33 (81.6)	0.359
IVIG	6 (46.2)	13 (35.1)	0.481
Outcomes
Invasive mycosis	5 (38.5)	1 (2.6)	0.0005
Total hospital staying, median (25%; 75%)	46 (21; 90)	24 (16; 30)	0.052
Duration of stay in ICU, days, median (25%; 75%)	30 (9; 46)	6 (4; 10)	0.003

Data presented as n (%). MIS-C: Multisystem inflammatory syndrome associated with coronavirus disease 2019 in children; ICU: Intensive care unit; IST: Immune-suppressive treatment; IVIG: Intravenous immunoglobulin.

Citation: Abramova NN, Avrusin IS, Kozlova OP, Firsova LA, Kuleshova AG, Kondratiev GV, Ivanov DO, Aleksandrovich YS, Kostik MM. Predictors of lethal outcome in patients with immunoinflammatory diseases hospitalized in the intensive care unit. World J Crit Care Med 2025; 14(3): 101890
URL: https://www.wjgnet.com/2220-3141/full/v14/i3/101890.htm
DOI: https://dx.doi.org/10.5492/wjccm.v14.i3.101890