Systematic review with expert consensus on use of extracorporeal hemoadsorption in septic shock: An Indian perspective

Table 2 Summary of consensus statements

Number	Summary of consensus statements
1	There is the need for adjuvant therapy (CytoSorb® haemoadsorption) in the management of refractory septic shock patients, when the standard of care is insufficient
2	In refractory septic shock cycle, CytoSorb® ideally be initiated within a maximum of 24 h after diagnosis and start of standard therapy
3	In the initiation of CytoSorb® therapy in refractory septic shock patient, IL-6 levels are not a pre-requisite or mandatory parameter for decision making
4	In a subset of patients, more than one CytoSorb® adsorber may be required to achieve sufficient haemodynamic stabilization
5	In continuation of CytoSorb® therapy, the absorber should be changed after 6-24 h depending on the clinical course and the machine type availability
6	CytoSorb® therapy is generally a safe therapy
7	Sepsis-induced AKI requiring RRT is not a prerequisite to initiate CytoSorb® therapy in refractory septic shock patients
8	The evaluation of the efficacy of CytoSorb® therapy should be based on endpoints like haemodynamic stabilization, inflammatory biomarkers, and/or improvement in the organ function, instead of mortality
9	The (displayed, Figure 2) flowchart can be helpful to a doctor very new to the therapy to ensure a certain level of best practice

AKI: Acute kidney injury; RRT: Renal replacement therapy.