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World J Crit Care Med. Sep 9, 2023; 12(4): 188-203
Published online Sep 9, 2023. doi: 10.5492/wjccm.v12.i4.188
Table 8 Soluble triggering receptor expressed on myeloid cells 1 for prognosis of sepsis
Ref.
Type of study
Patient population
Aim
No. of patients/studies
Results
Conclusion of study
Su et al[67], 2016Systematic review AdultsTo determine prognostic value of sTREM1 in predicting mortality at the initial stage of infection9 studiesHigh sTREM1 level was associated with higher risk of death in infection, with pooled RR 2.54 (95%CI: 0.61-0.86) using a random effects model; Pooled sensitivity and specificity of sTREM1 to predict mortality in infection were 0.75 (95%CI: 0.61-0.86) and 0.66 (95%CI: 0.54-0.75), respectivelyHigher sTREM1 levels had a moderate prognostic significance in assessing the mortality of infection in adult patients; however sTREM1 alone is not sufficient to predict mortality as a marker
Su et al[68], 2012ObservationalAdults To study the association of sepsis prognosis with dynamic changes in sTREM1 and its polymorphisms160sTREM1 levels were significantly raised in non survivors than in survivors (P < 0.001); Logistic regression showed that sTREM1, APACHE 2, and rs2234237 polymorphisms are risk factors for prognosisDynamic changes in sTREM1 and rs2234237 polymorphism could be used for prognostication in septic patients
Wang et al[69], 2011ObservationalAdults To observe dynamic changes in plasma sTREM1 levels and to study its effect on predicting outcome of septic patients combined with SOFA score57Non survivors-sTREM1 levels were highest on Day 1 and a gradual elevation was seen over days 1, 3 and 7). Survivor-sTREM levels were highest on day 1 and then showed a gradual reduction over days 1, 3 and 7. sTREM levels were significantly higher in non survivors as compared to survivors (P < 0.01)High plasma levels of sTREM1 are detected at initial stages in septic patients and sTREM1 level combined with SOFA score may be helpful in predicting outcomes in septic patients
RR: Risk ratio; sTREM1: Soluble triggering receptor expressed on myeloid cells 1.