Neutrophil kinetics and function after major trauma: A systematic review

Figure 2 Schematical representation of neutrophil changes over time following major trauma, differentiated by complicated or uncomplicated clinical course. Complicated course indicates subsequent sepsis or multiple organ dysfunction, where evidence exists in the literature. A: Neutrophil number post injury relative to pre-injury/control levels; B: Neutrophil responsiveness (CD11b or FC Gamma receptor II upregulation in response to fMLP) following injury relative to control; C: Immunosuppressive CD16^bright/CD62L^dim neutrophils as percentage of total neutrophils relative to control. No data exist for the presence of these cells more than 4 d after trauma or in complicated/uncomplicated courses.