Development of a nomogram for predicting a positive repeat prostate biopsy

Table 4 Published nomograms to predict positive prostate biopsy in repeat biopsy

Ref.	No. of patients	AUC	AUC of external validation	No of factors	Nomogram factors	Mean of no of biopsy cores	Ca detection rate, %
Lopez-Corona et al[9,12]	343	0.700	0.710	8	Standard factors + PSAV, HGPIN, ASAP, No. of total cores, biopsy history, family history	9.15	20
2Walz et al[10]	161	0.720	-	9	Age, PSA, %free PSA, PSA density, TZ density, prostate volume, TZ volume, no of previous biopsy, no of cores.	24	41
Chun et al[11]	1082	0.760	0.68-0.78	6	Standard factors, prostate volume, biopsy history, %free PSA, sampling density	11.1	30.2
Benecchi et al[13]	419	-	0.856	7	DRE + PSA slope, HGPIN, %free PSA, PSA density	-	31
Rochester et al[14]	110	0.818	0.696	7	Standard factors + PSA velocity, HGPIN, biopsy history, %free PSA	-	30-31
Chun et al[15,16]	809	0.700	0.73-0.751	6	Standard factors + prostate volume, biopsy history, PCA3	15	39.1
Moussa et al[17]	408	0.720	0.620	12	Standard factors + prostate volume, PSA velocity, HGPIN, ASAP, No. of total cores, family history, time from initial/previous biopsy, BMI	19.1	31.6
2Sakura et al[18]	515	0.791	-	5	Age, %free PSA, prostate volume, previous extended biopsy, PSA doubling time	26	31.6
Present series	459	0.740	-	16	Age, No. of biopsy core, PSA, PSA density, prostate volume, TZ volume, PSA TZ density, TRUS, DRE, HGPIN, ASAP, months from initial biopsy and previous biopsy, No. of previous negative biopsy, PSA slope	11.4	17

¹Standard factors include age, PSA and digital rectal examination;

²Extended biopsy. AUC: Area under the curves; TZ: Transitional zone; TRUS: Transrectal ultrasonography; HGPIN: High grade prostatic intraepithelial neoplasia; ASAP: Atypical small acinar proliferation; PSA: Prostatic specific antigen,DRE: Digital rectal exam; BMI: Body-mass index.