Prevention of necrotizing enterocolitis in premature infants – an updated review

Table 1 Summary of five randomized controlled trials of human milk feeding on the risk of necrotizing enterocolitis

Ref.	Yr	GA	BW	N	Study	Control	NEC ≥ stage II, %			Mortality, %			LOS, %
							Study	Control	P < 0.05	Study	Control	P < 0.05	Study	Control	P < 0.05
Corpeleijn et al[8]	2016	-	< 1500	373	DM	PF	9.3	8.9	No	13.7	12.7	No	36.6	34.7	No
Cristofalo et al[9]	2013	-	500-1250	53	HM	PF	3	21	Yes	0	8	No	55	79	No
Sullivan et al[10]	2010	-	500-1250	207	HM	Bovine milk	5.8	15.9	Yes	-	-	-	19	13	No
Schanler et al[11]	2005	< 30	-	243	DM	PF	6	9	No	3	3.6	No	1	4.8	No
Schanler et al[12]	1999	26-30	-	108	HM	PF	1.6	13	Yes	-	-	-	31	48	Yes

BW: Birth weight; LOS: Late onset sepsis; NEC: Necrotizing enterocolitis.