Potential for treatment of severe autism in tuberous sclerosis complex

Table 1 Criteria for clinical diagnosis of tuberous sclerosis complex

Major features	Minor features
Cortical tubers	Dental enamel pits
Subependymal nodules	Hamartomatous rectal polyps
Subependymal giant cell astrocytoma	Bone cysts
Hypomelanotic macules (3 or more)	Cerebral white matter radial migration lines
Shagreen patch	Gingival fibromas
Facial angiofibromas or forehead plaque	Nonrenal hamartoma
Multiple renal nodular hamartomas	Retinal achromatic patches
Nontraumatic ungual or periungual fibromas	“Confetti” skin lesions
Cardiac rhabdomyoma, 1 or >	Multiple renal cysts
Pulmonary Lymphangiomyomatosis and/or renal angiomyolipomas

Tuberous sclerosis complex (TSC) can be clinically diagnosed as definite, probable, or possible based on the presence or absence of a specific combination of major and minor features. Definite TSC: two major features or one major and two minor features; Probable TSC: one major and one minor feature; Possible TSC: one major feature or two or more minor features.