Early lactase enzyme supplementation: Efficacy to promote growth and feeding tolerance in preterm infants: A randomized controlled trial

doi:10.5409/wjcp.124805

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Dec 9, 2026; 15(4): 124805
Published online Dec 9, 2026. doi: 10.5409/wjcp.124805

Table 7 Primary and secondary outcomes between the studied groups, n (%)/mean ± SD

Variable	Intervention group (n = 55)	Control group (n = 54)	P value
Primary outcome
Weight gain (g/day)	18.9 ± 9.5	12.3 ± 6.3	< 0.0001
Days to reach full enteral feeding (days)	15.0 ± 8.24	16.9 ± 8.45	0.250
NEC incidence	3 (5.5)	10 (18.5)	0.0448
Secondary outcome
Sepsis incidence	8 (14.5)	8 (14.8)	1.0
Hospital stay (days)	23.6 ± 8.24	25.7 ± 8.45	0.339
Fate
Discharged	47 (85.5)	46 (85.2)	1.0
Died	8 (14.5)	8 (14.8)	1.0

NEC: Necrotizing enterocolitis.

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Citation: Morsi WEMA, Eskander AE, Mostafa MG, Ezz ElDin Z, Abdel Maksoud FA, Elrefaee A. Early lactase enzyme supplementation: Efficacy to promote growth and feeding tolerance in preterm infants: A randomized controlled trial. World J Clin Pediatr 2026; 15(4): 124805
URL: https://www.wjgnet.com/2219-2808/full/v15/i4/124805.htm
DOI: https://dx.doi.org/10.5409/wjcp.124805

Morsi WEMA, Eskander AE, Mostafa MG, Ezz ElDin Z, Abdel Maksoud FA, Elrefaee A. Early lactase enzyme supplementation: Efficacy to promote growth and feeding tolerance in preterm infants: A randomized controlled trial. World J Clin Pediatr 2026; 15(4): 124805 [DOI: 10.5409/wjcp.124805]

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