Early lactase enzyme supplementation: Efficacy to promote growth and feeding tolerance in preterm infants: A randomized controlled trial

doi:10.5409/wjcp.124805

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Dec 9, 2026; 15(4): 124805
Published online Dec 9, 2026. doi: 10.5409/wjcp.124805

Table 4 Feeding intolerance parameters between the studied groups at the 1^st and 2^nd week, n (%)

Variable	Intervention group (n = 55)	Control group (n = 54)	P value
Gastric residual
1^st week	13 (23.6)	32 (59.3)	0.0002
2^nd week	9 (16.4)	23 (42.6)	0.003
Abdominal distension
1^st week	31 (56.4)	44 (81.5)	0.007
2^nd week	14 (25.5)	40 (74.1)	< 0.001
Emesis
1^st week	5 (9.1)	19 (35.2)	0.001
2^nd week	1 (1.8)	2 (3.7)	0.62
Diarrhea
1^st week	3 (5.5)	14 (25.9)	0.004
2^nd week	1 (1.8)	11 (20.4)	0.002

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Citation: Morsi WEMA, Eskander AE, Mostafa MG, Ezz ElDin Z, Abdel Maksoud FA, Elrefaee A. Early lactase enzyme supplementation: Efficacy to promote growth and feeding tolerance in preterm infants: A randomized controlled trial. World J Clin Pediatr 2026; 15(4): 124805
URL: https://www.wjgnet.com/2219-2808/full/v15/i4/124805.htm
DOI: https://dx.doi.org/10.5409/wjcp.124805

Morsi WEMA, Eskander AE, Mostafa MG, Ezz ElDin Z, Abdel Maksoud FA, Elrefaee A. Early lactase enzyme supplementation: Efficacy to promote growth and feeding tolerance in preterm infants: A randomized controlled trial. World J Clin Pediatr 2026; 15(4): 124805 [DOI: 10.5409/wjcp.124805]

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