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Systematic Reviews
Copyright: ©Author(s) 2026.
World J Clin Pediatr. Dec 9, 2026; 15(4): 124374
Published online Dec 9, 2026. doi: 10.5409/wjcp.124374
Table 5 Summary of certainty of evidence by comparison category
Comparison category
Direction of findings
Main limitations
Certainty of evidence
Unstructured PPIA vs parental absence or standard careMixed; some trials showed reduced anxiety, while others showed no clinically meaningful induction benefitHeterogeneity in timing, comparator, parental role, and outcome measurement; limited blindingLow to moderate
PPIA vs sedative premedicationSedative premedication generally produced more reliable reduction in induction anxietyLimited number of direct comparisons; different sedative protocolsModerate
Active or coached parental involvement vs passive presenceActive/coached approaches appeared more favorable than passive presenceFew trials; intervention protocols differed; limited precisionLow
Multimodal parental involvementPotential benefit when combined with preparation, behavioral support, or selected pharmacological anxiolysisDifficult to isolate effect of parental involvement from adjunctive interventionLow
Virtual parental presenceFeasible and promising, especially when combined with coachingPilot-level evidence; small sample size; technology and implementation variabilityVery low to low


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