Non-nutritional rickets: Approach, precision medicine, and outcomes

doi:10.5409/wjcp.122166

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Dec 9, 2026; 15(4): 122166
Published online Dec 9, 2026. doi: 10.5409/wjcp.122166

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Figure 4 Indices to ascertain renal phosphorus wasting in hypophosphatemia. ¹Falsely low values in severe hypophosphatemia. ²May be used across all ranges of TRP and falsely low values in severe hypophosphatemia. ³Limitations: (1) Ideally requires oral phosphorus Loading; (2) Nomogram established for adults - children have physiologically higher serum phosphorus levels; (3) Overestimates tubular maximum reabsorption of phosphate/glomerular filtration rate if TRP > 0.8; and (4) Falsely low values in severe hypophosphatemia. U_Phosphate: Urinary phosphate; U_Creatinine: Urinary creatinine; P_Phosphate: Plasma phosphate, P_Creatinine: Plasma creatinine; TP: Tubular phosphate; GFR: Glomerular filtration rate; TRP: Tubular reabsorption of phosphate; PO₄: Phosphorus; TmP: Tubular maximum reabsorption of phosphate.

Citation: Pathak PP, Ray S. Non-nutritional rickets: Approach, precision medicine, and outcomes. World J Clin Pediatr 2026; 15(4): 122166
URL: https://www.wjgnet.com/2219-2808/full/v15/i4/122166.htm
DOI: https://dx.doi.org/10.5409/wjcp.122166

Pathak PP, Ray S. Non-nutritional rickets: Approach, precision medicine, and outcomes. World J Clin Pediatr 2026; 15(4): 122166 [DOI: 10.5409/wjcp.122166]

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