Does Takayasu arteritis differ between children and adolescents? Insights from a Russian multicenter cohort

Table 2 Clinical manifestations at disease onset in the total cohort and stratified by age group (< 10 years vs ≥ 10 years), n (%)

Parameter	Total cohort (n = 79)	Total cohort (n = 79), %, 95%CI	< 10 years	≥ 10 years	P value
Malaise	67	84.8, 75.0-91.9	18 (72.0)	49 (90.7)	0.044
Fever	43	54.4, 42.8-65.7	10 (40.0)	33 (61.1)	0.080
Headache	37	46.8, 35.5-58.4	11 (44.0)	26 (48.1)	0.731
Arthralgia	21	26.6, 17.3-37.7	4 (16.0)	17 (31.5)	0.179
Arthritis	5	6.3, 2.1-14.2	0 (0.0)	5 (9.3)	0.173
Weight loss	20	25.3, 16.2-36.4	4 (16.0)	16 (29/6)	0.269
Myalgia	14	17.7, 10.0-27.9	4 (16.0)	10 (18.5)	1.000
Abdominal pain	14	17.7, 10.0-27.9	6 (24.0)	8 (14.8)	0.353
Limb claudication	21	26.6, 17.3-37.7	10 (40.0)	11 (20.4)	0.099
Limb numbness	13	16.5, 9.1-26.5	4 (16.0)	9 (16.7)	1.000
Diminished/absent pulse	25	31.6, 21.6-43.1	8 (32.0)	17 (31.5)	1.000
Vascular bruits	43	54.4, 42.8-65.7	11 (44.0)	32 (59.3)	0.205
Blood pressure difference between extremeties ≥ 10 mmHg	22	27.8, 18.3-39.1	7 (28.0)	15 (27.8)	1.000
Carotidynia	11	13.9, 7.2-23.5	2 (8.0)	9 (16.7)	0.487
Arterial hypertension	28	35.4, 25.0-47.0	9 (36.0)	19 (35.2)	1.000
Vascular pain	21	26.6, 17.3-37.7	5 (20.0)	16 (29.6)	0.424
Epistaxis	4	5.1, 1.4-12.5	3 (12.0)	1 (1.9)	0.091
Lymphadenopathy	7	8.9, 3.6-17.4	1 (4.0)	6 (11.1)	0.422
Hearing loss	1	1.3, 0.0-6.9	0 (0.0)	1 (1.9)	1.000
Nausea	4	5.1, 1.4-12.5	0 (0.0)	3 (5.6)	1.000
Syncope	8	10.1, 4.5-19.0	3 (12.0)	5 (9.3)	0.703
Dizziness	8	10.1, 4.5-19.0	1 (4.0)	7 (13.0)	0.424
Visual impairment	4	5.1, 1.4-12.5	0 (0.0)	4 (7.4)	0.302