Microbial and functional shifts between flare and remission in a single-center cohort of children with inflammatory bowel disease

Figure 4 Microbial functional pathways associated with significantly altered microbial genes in remission (visit 2) compared with flare (visit 1) states of inflammatory bowel disease. A: Top 30 microbial functional pathways associated with microbial genes exhibiting significant differential abundance (≥ 2-fold change) in remission (visit 2) compared with flare (visit 1); B: Major metabolic pathway categories, including vitamin and cofactor biosynthesis, carbohydrate metabolism, amino acid metabolism, and lipid and fatty acid metabolism, associated with microbial genes significantly altered in remission (visit 2) compared with flare (visit 1). SCFA: Short-chain fatty acid; BCAA: Branched-chain amino acids.