Clinical and laboratory manifestations and treatment of children with TNFRSF1A gene variants

doi:10.5409/wjcp.119428

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World Journal of Clinical Pediatrics

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2219-2808

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Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Sep 9, 2026; 15(3): 119428
Published online Sep 9, 2026. doi: 10.5409/wjcp.119428

Table 3 Laboratory parameters of patients with TNFRSF1A gene variants and systemic juvenile idiopathic arthritis at disease onset the and at the time of systemic juvenile idiopathic arthritis diagnosis, median (interquartile range)

Laboratory indicators	Normal values	Total group (n = 66)	*Patients with gene variants TNFRSF1A(n = 33)*	Patients with sJIA (n = 33)	P value	Total group (n = 66)	*Patients with gene variants TNFRSF1A(n = 33)*	Patients with sJIA (n = 33)	P value
Red blood cells, (million/mL)	4-5.2	4.0 (3.6-4.2)	4.0 (3.8-4.2)	3.9 (3.4-4.0)	0.06	4.4 (3.9-4.8)	4.27 (3.8-5.01)	4.4 (4.01-4.7)	0.97
Hemoglobin (g/L)	115-145	100 (94-104)	101 (95-106)	98 (90-102)	0.03	110 (101-119.2)	108 (101-118)	112 (100-120)	0.45
Leukocytes (thousand/mL)	4.5-11.5	17.9 (12.3-22.7)	12.6 (11.2-18.8)	20.3 (17.8-24.2)	0.0001	12.7 (8.9-17)	11.2 (8.9-15.2)	13.5 (9.9-18.6)	0.27
Neutrophils (thousand/mL)	1.1-9.9	14.5 (8.5-18.2)	9.1 (6.7-14.6)	17.6 (14.5-19.1)	0.0001	8.8 (4.8-12.2)	7.6 (4.3-10.2)	9.9 (5.7-13.2)	0.13
Platelets (thousand/mL)	150-450	456 (353.3-599)	415 (334-456)	556 (456-660)	0.0001	410 (340-521.5)	372 (316-469)	425 (353-528)	0.19
ESR (mm/hour)	0-20	53 (37-61)	45 (35-60)	55 (43-60)	0.2	34.5 (15-52)	34 (15-52)	35 (24-52)	0.93
СRP (mg/L)	< 5	66.5 (34.1-115.7)	47.5 (26.7-68)	84.7 (60-128)	0.001	37.8 (10.5-102)	43 (7.8-102.4)	40.5 (11.2-92.8)	0.86
ALT (U/L)	< 40	24 (20-34)	23 (20-30)	24 (20-46)	0.31	16 (11.8-24.5)	19 (11-26)	15 (12-24)	0.89
AST (U/L)	< 42	27.5 (23-36)	26 (20-35)	30 (24-40)	0.19	25.5 (22-33.2)	28 (23-37)	24 (20-30)	0.1
LDH (U/L)	91-295	243.5 (203-289)	228 (167-284)	246 (225-289)	0.09	243 (198-301.5)	237 (173-301)	247 (200-298)	0.46
Ferritin (ng/mL)	12-84	113.5 (75.7-259)	102.3 (67.6-227.4)	167.9 (98.6-357.9)	0.03	120.3 (53.3-473.2)	129.3 (54.2-349.2)	118.9 (65.7-450.4)	0.65
Physician's VAS, (mm)	0-100					56.5 (33.8-70)	65 (48-76)	74 (56-80)	0.005
Parent/patient's VAS (mm)	0-100					64.5 (44-74.3)	70 (54-78)	78 (40-70)	0.26
CHAQ	0-3					0.75 (0.125-1)	0.75 (0.5-1.5)	0.5 (0.125-0.75)	0.002
JADAS71						17.4 (13-22.6)	16.2 (12-21.5)	18.6 (15.5-25)	0.37

sJIA: Systemic juvenile idiopathic arthritis; ESR: Erythrocyte sedimentation rate; CRP: C-reactive protein; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; LDH: Lactate dehydrogenase; VAS: Visual analogue scale; CHAQ: Childhood Health Assessment Questionnaire; JADAS71: Juvenile arthritis disease activity score 71.

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Citation: Alexeeva EI, Shingarova MS, Dvoryakovskaya TM, Isaeva KB, Chomakhidze AM, Fetisova AN, Chibisova KV, Krekhova EA, Kriulin IA, Kriulina TY, Tsulukiya IT, Botova MS, Kondratyeva NM, Kokina MY, Makunc AA, Dostiev NA, Savostyanov KV, Pushkov AA, Zhanin IS, Demyanov DS, Kostik MM. Clinical and laboratory manifestations and treatment of children with TNFRSF1A gene variants. World J Clin Pediatr 2026; 15(3): 119428
URL: https://www.wjgnet.com/2219-2808/full/v15/i3/119428.htm
DOI: https://dx.doi.org/10.5409/wjcp.119428

Alexeeva EI, Shingarova MS, Dvoryakovskaya TM, Isaeva KB, Chomakhidze AM, Fetisova AN, Chibisova KV, Krekhova EA, Kriulin IA, Kriulina TY, Tsulukiya IT, Botova MS, Kondratyeva NM, Kokina MY, Makunc AA, Dostiev NA, Savostyanov KV, Pushkov AA, Zhanin IS, Demyanov DS, Kostik MM. Clinical and laboratory manifestations and treatment of children with TNFRSF1A gene variants. World J Clin Pediatr 2026; 15(3): 119428 [DOI: 10.5409/wjcp.119428]

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