Pediatric migraine: Neurodevelopmental mechanisms, clinical phenotypes, and modern therapeutics

doi:10.5409/wjcp.v15.i2.119843

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Jun 9, 2026; 15(2): 119843
Published online Jun 9, 2026. doi: 10.5409/wjcp.v15.i2.119843

Table 5 Comparative overview of traditional vs emerging acute therapies

Feature	Triptans	Gepants (emerging)	Ditans (emerging)
Primary target	5-HT_1B/1D	CGRP receptor	5-HT_1F receptor
Vasoconstriction	Yes	No	No
Primary SE	Chest/neck tightness	Nausea, dry mouth	Dizziness, somnolence
Pediatric status	FDA/EMA approved (selected)	Phase 3 trials (6-17 years)	Ongoing trials (6-17 years)
Clinical role	Standard 2^nd-line	Refractory/vascular contraindication	Refractory/vascular contraindication

SE: Side effects; EMA: European Medicines Agency; FDA: Food and Drug Administration; CGRP: Calcitonin gene-related peptide.

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Citation: Al-Beltagi M. Pediatric migraine: Neurodevelopmental mechanisms, clinical phenotypes, and modern therapeutics. World J Clin Pediatr 2026; 15(2): 119843
URL: https://www.wjgnet.com/2219-2808/full/v15/i2/119843.htm
DOI: https://dx.doi.org/10.5409/wjcp.v15.i2.119843

Al-Beltagi M. Pediatric migraine: Neurodevelopmental mechanisms, clinical phenotypes, and modern therapeutics. World J Clin Pediatr 2026; 15(2): 119843 [PMID: 42220944 DOI: 10.5409/wjcp.v15.i2.119843]

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