Pediatric migraine: Neurodevelopmental mechanisms, clinical phenotypes, and modern therapeutics

Table 3 Standardized acute pharmacotherapy: Weight-based dosing

Agent	Pediatric dose (mg/kg)	Max single dose	Monthly limit	Monitoring/safety
Ibuprofen	10 mg/kg	800 mg	< 14 days/month	Take with food; avoid in active gastritis or renal impairment
Acetaminophen	15 mg/kg	1000 mg	< 14 days/month	Hepatic safety; check for “hidden” sources in OTC products
Naproxen	5-10 mg/kg	500 mg	< 14 days/month	Preferred for long-duration attacks due to 12 hours half-life
Sumatriptan	Nasal spray: 5-20 mg	20 mg	< 9 days/month	Monitor for “triptan sensations” (chest/neck tightness)

OTC: Over-the-counter.