Enigma of autism regression mechanistic pathways, clinical phenotypes, and early intervention implications

doi:10.5409/wjcp.v15.i2.118495

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Jun 9, 2026; 15(2): 118495
Published online Jun 9, 2026. doi: 10.5409/wjcp.v15.i2.118495

Table 9 Intervention strategies tailored to regression phenotypes

Regression phenotype	Primary goal	Key strategy
Language-dominant	Rebuild expressive communication	Combined speech therapy + AAC
Social-communicative	Re-establish “social connection”	NDBIs focusing on joint attention and imitation
Global/mixed	Stabilize biological environment	Medical workup + OT for sensory regulation
Epileptic-associated	Reduce “neural noise”	Targeted anti-epileptic treatment + behavioral support

NDBI: Naturalistic developmental behavioral intervention; AAC: Augmentative communication; OT: Occupational therapy.

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Citation: Al-Beltagi M. Enigma of autism regression mechanistic pathways, clinical phenotypes, and early intervention implications. World J Clin Pediatr 2026; 15(2): 118495
URL: https://www.wjgnet.com/2219-2808/full/v15/i2/118495.htm
DOI: https://dx.doi.org/10.5409/wjcp.v15.i2.118495

Al-Beltagi M. Enigma of autism regression mechanistic pathways, clinical phenotypes, and early intervention implications. World J Clin Pediatr 2026; 15(2): 118495 [PMID: 42220948 DOI: 10.5409/wjcp.v15.i2.118495]

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