Circulating levels of growth differentiation factor-15 and its genetic variants -3148C>G (rs4808793) in pediatric cardiac patients

doi:10.5409/wjcp.v15.i2.117283

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World Journal of Clinical Pediatrics

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2219-2808

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Jun 9, 2026; 15(2): 117283
Published online Jun 9, 2026. doi: 10.5409/wjcp.v15.i2.117283

Table 4 Genotypes and allele frequencies of growth differentiation factor-15 rs4808793 (-3148C>G) single-nucleotide polymorphism among congenital heart diseases and controls

Study groups	Variables
	GDF-15 rs4808793 (-3148C>G) genotypes														GDF-15 rs4808793 (-3148C>G) alleles
	CC		CG		GG		CC + CG		GG		CC		CG + GG		C		G
	n	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%
Congenital heart diseases (n = 69)	31	44.9	33	47.8	5	7.2	64	92.4	5	7.6	31	44.9	38	55.1	95	68.8	43	31.2
Control (n = 50)	5	10	34	68	11	22	39	78	11	22	5	10	45	90	44	44	56	56
P value (χ²)	< 0.001 (16.252)						0.020 (5.423)				< 0.001 (16.762)				< 0.001 (14.728)
OR (95%CI)	-						3.610 (1.167-11.172)				7.342 (2.599-20.743)				2.812 (1.648-4.799)

GDF-15: Growth differentiation factor-15; OR: Odds ratio; CI: Confidence interval.

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Citation: Abd-Elmawgood EA, Hassan MH, Abd-Elbaseer KA, Ibrahem MH, Yousef KMH, Bakri AH. Circulating levels of growth differentiation factor-15 and its genetic variants -3148C>G (rs4808793) in pediatric cardiac patients. World J Clin Pediatr 2026; 15(2): 117283
URL: https://www.wjgnet.com/2219-2808/full/v15/i2/117283.htm
DOI: https://dx.doi.org/10.5409/wjcp.v15.i2.117283

Abd-Elmawgood EA, Hassan MH, Abd-Elbaseer KA, Ibrahem MH, Yousef KMH, Bakri AH. Circulating levels of growth differentiation factor-15 and its genetic variants -3148C>G (rs4808793) in pediatric cardiac patients. World J Clin Pediatr 2026; 15(2): 117283 [PMID: 42220965 DOI: 10.5409/wjcp.v15.i2.117283]

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