Evaluation of heart rate variability in pediatric patients with beta thalassemia major: Cross-sectional study

doi:10.5409/wjcp.v15.i2.116098

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World Journal of Clinical Pediatrics

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2219-2808

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World J Clin Pediatr. Jun 9, 2026; 15(2): 116098
Published online Jun 9, 2026. doi: 10.5409/wjcp.v15.i2.116098

Table 4 Comparison of heart rate variability parameters between patients with and without arrhythmia, mean ± SD/median (25^th-75^th percentiles)

Parameter	With arrhythmia (n = 19)	Without arrhythmia (n = 21)	P value
Minimum HR (bpm)	63.76 ± 13.16	62.89 ± 13.30	0.837
Maximum HR (bpm)	161.4 ± 19.43	161.4 ± 14.34	0.999
Average HR (bpm)	101.2 ± 11.50	99.89 ± 14.83	0.749
SDNN (ms)	78.24 ± 28.67	80.21 ± 36.26	0.649
SDANN5 (ms)	72.43 ± 23.28	76.63 ± 24.69	0.503
SDNN index (ms)	38.71 ± 11.83	45.00 ± 17.34	0.236
RMSSD (ms)	25.76 ± 13.17	31.37 ± 14.24	0.204
pNN50 (%)	7.48 ± 7.87	10.53 ± 8.30	0.169
HF power (ms²)	326.6 (254.7-349.7)	320.2 (234.4-492.1)	0.776
LF power (ms²)	667.3 (595.7-759.3)	674.2 (447.9-899.9)	0.745
VLF power (ms²)	1289.5 (1234.1-1400.5)	1234.8 (890.8-1436.5)	0.626
LF/HF ratio	1.99 (1.78-2.45)	2.29 (1.57-2.71)	0.818

HR: Heart rate; SDNN: Standard deviation of all normal-to-normal intervals; SDANN: Standard deviation of 5-minute average normal-to-normal intervals; RMSSD: Root mean square of successive differences; pNN50: Percentage of normal-to-normal intervals differing by > 50 ms; LF: Low frequency; HF: High frequency; VLF: Very low frequency.

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Citation: Sorour EA, Elaskary EM, Elnemr SB, Hagag AA, Kassab NA, Al-Beltagi M. Evaluation of heart rate variability in pediatric patients with beta thalassemia major: Cross-sectional study. World J Clin Pediatr 2026; 15(2): 116098
URL: https://www.wjgnet.com/2219-2808/full/v15/i2/116098.htm
DOI: https://dx.doi.org/10.5409/wjcp.v15.i2.116098

Sorour EA, Elaskary EM, Elnemr SB, Hagag AA, Kassab NA, Al-Beltagi M. Evaluation of heart rate variability in pediatric patients with beta thalassemia major: Cross-sectional study. World J Clin Pediatr 2026; 15(2): 116098 [PMID: 42220932 DOI: 10.5409/wjcp.v15.i2.116098]

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