Role of TRPM4 ion channel in pediatric arrhythmic syndromes

Figure 1 Overall architecture of the hTRPM4 subunit. A: A schematic representation of the major structural components in hTRPM4; the N-terminus has four melastatin regions and Pre-S1 region; the transmembrane domain contains six helices (S1-S6); helices S5, S6 and P-loop form pore module; the C-terminus contains transient receptor potential and C-terminal domain helices; alpha-helices are represented by cylinders and beta-strands are indicated by arrows; variants are numbered: 1-E7K; 2-R164W; 3-D198G; 4-A432T; 5-V441M; 6-R499W; 7-G582S; 8-T677I; 9-P779R; 10-R819C; 11-G844D; 12-T873I; 13-K914X; 14-V921I; 15-R964S; 16-L1075P; 17-K1140X; B: 3D model of the hTRPM4 subunit (PDB ID: 5WP6). MHR1-4: Four melastatin regions; TM: Transmembrane; TRP: Transient receptor potential; CTD: C-terminal domain.