Role of soluble alpha-klotho as a novel biomarker for characterizing children with autism spectrum disorder in Kurdistan, Iraq

Table 8 Receiver operating characteristic analysis results of soluble alpha-klotho for autism spectrum disorder prediction

Parameters	Area under the curve	SE1	Asymptotic sig2	Asymptotic 95%CI		Cut off value	Sensitivity	Specificity	Youden index
				Lower bound	Upper bound
S-KLα	0.91	0.0225	0.001	0.866	0.954	120 pg/mL	0.822	0.94	0.76
Vit-D3	0.9	0.0224	0.000	0.85	0.94	37.3 ng/mL	0.8	0.76	0.8
Creatinine	0.66	0.0381	0.000	0.58	0.74	0.48 mg/dL	0.93	0.81	0.35
Glucose	0.97	0.0118	0.000	0.94	0.99	99 mg/dL	0.98	0.75	0.86
Uric acid	0.92	0.0198	0.000	0.88	0.96	5.1 mg/dL	0.93	0.72	0.65
Iron	0.87	0.0256	0.000	0.87	0.92	86 μg/dL	0.8	0.81	0.61
HGB	0.79	0.0316	0.000	0.73	0.85	12.3 g/dL	0.56	0.48	0.48
Age	0.58	0.0400	0.037	0.51	0.67	10 years	0.62	0.53	0.15

¹Under the nonparametric assumption.

²Null hypothesis: True area = 0.5.

CI: Confidence interval; HGB: Hemoglobin; SE: Standard error; S-KLα: Soluble alpha-klotho; Vit-D3: Vitamin D3.