Could high serum C-reactive protein levels serve as a biomarker for children and adolescents diagnosed with generalized anxiety disorder?

Table 2 Comparison of biochemical measure levels between the generalized anxiety disorder and control groups, median (interquartile range)

	GAD group (n = 25)	Control group (n = 30)	P value1
CRP (mg/L)	1.7 (1.2-2.94)	1.3 (1.2-1.7)	0.034
TNF-α (pg/mL)	7.9 (6.4-11.0)	9.3 (7.7-11.0)	0.466
TWEAK (mg/L)	1111 (893-1889)	1236 (1009-1380)	0.980
IL-6 (pg/mL)	2.8 (0.75-3.99)	2.8 (0.8-4.0)	0.615
IFN-γ (ng/mL)	59.4 (38.4-95.4)	61.6 (54-84)	0.628
Zinc (μg/dL)	94 (82-104)	100 (93-112)	0.073
Neopterin (nmol/L)	3.66 (1.84-4.74)	2.9 (2.2-3.9)	0.674

¹Mann-Whitney U test.

CRP: C-reactive protein; TNF: Tumor necrosis factor; TWEAK: Tumor necrosis factor-like weak inducer of apoptosis; IL: Interleukin; IFN: Interferon; GAD: Generalized anxiety disorder.