Pharmacological treatment of obsessive-compulsive disorder in children and adolescents: An overview

Table 2 Studies examining the use of antipsychotics in resistant obsessive-compulsive disorder

Ref.	Study design	Sample size	Population	Medication (dose)	Response	Side effects
Masi et al[43]	Open label	39	Adolescents with SSRI-resistant OCD	Aripiprazole (12.2 ± 3.4 mg)	59.5% responded	Mild agitation and sleep disturbances (approximately of 10% of cohort)
Masi et al[44]	Open label	69	Children with tic-related OCD	Risperidone (1.7 ± 0.8 mg) or aripiprazole (8.9 ± 3.1 mg)	56.5% responded	Risperidone: Weight gain, sedation. Aripiprazole: Mild to moderate agitation
Akyol Ardic et al[45]	Retrospective chart review	48	Children and adolescents with treatment resistant OCD	Aripiprazole (3.4 ± 2.2 mg)	Significant improvement in YBOCS/CGI scores	Statistically significant weight gain

SSRI: Selective serotonin reuptake inhibitors; OCD: Obsessive compulsive disorder; YBOCS: Yale-Brown Obsessive Compulsive Scale; CGI: Clinical Global Impression.