Neonatal cholestasis is associated with cytochrome P450 1A2 detoxification defect: A single center pilot study

Table 3 Cytochrome P450 1A2 levels according to age among biliary atresia, neonatal hepatitis and control groups

Age groups	CYP1A2 (ng/mL)	BA group (n = 20)	NH group (n = 20)	Control group (n = 20)	P value
1 month subgroup	n	n = 7	n = 2	n = 6	0.006a
	mean ± SD	13.58 ± 9.73	9.59 ± 9.95	31.68 ± 12.33
	Range	4.3-33.9	1.3-19	18.3-50
2 months subgroup	n	n = 8	n = 4	n = 8	0.007a
	mean ± SD	12.84 ± 11.91	6.72 ± 6.4	34.29 ± 13.63
	Range	3.6-33.5	0.5-15.7	11.8-47.7
3 months subgroup	n	n = 5	n = 14	n = 6	0.01
	mean ± SD	12.84 ± 8.73	10.8 ± 11	27.1 ± 11.49
	Range	3.5-24	0.5-26	12-39.7

^aP < 0.05.

CYP1A2: Cytochrome P450 1A2; BA: Biliary atresia; NH: Neonatal hepatitis.