Neonatal cholestasis is associated with cytochrome P450 1A2 detoxification defect: A single center pilot study

doi:10.5409/wjcp.v15.i1.113478

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Mar 9, 2026; 15(1): 113478
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.113478

Table 2 Cytochrome P450 1A2 of both studied groups with cholestasis compared to control group

CYP1A2 (ng/mL)	BA group (n = 20)	NH group (n = 20)	Control group (n = 20)	Test of significance	P value
Median (IQR)	11.35 (5.2-19.25)	4.5 (1-16.75)	34.15 (18.48-40.9)	KW = 26.05	P1 = 0.1
mean ± SD	13.58 ± 9.73	9.59 ± 9.95	31.68 ± 12.33	KW = 26.05	P2 = 0.001^a
Range	3.5-33.9	0.5-32	11.8-50	P = 0.001^a	P3 = 0.001^a

^aP < 0.05.

CYP1A2: Cytochrome P450 1A2; BA: Biliary atresia; IQR: Interquartile range; KW: Kuskal Wallis; NH: Neonatal hepatitis; P1: The difference between biliary atresia and neonatal hepatitis groups; P2: The difference between biliary atresia group and the control group; P3: The difference between neonatal hepatitis group and the control group.

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Citation: Kotb MA, Wilson MM, Shafik AN, Ahmed NA, Fahim VF, Lotfi NA, Eissawy YM. Neonatal cholestasis is associated with cytochrome P450 1A2 detoxification defect: A single center pilot study. World J Clin Pediatr 2026; 15(1): 113478
URL: https://www.wjgnet.com/2219-2808/full/v15/i1/113478.htm
DOI: https://dx.doi.org/10.5409/wjcp.v15.i1.113478

Kotb MA, Wilson MM, Shafik AN, Ahmed NA, Fahim VF, Lotfi NA, Eissawy YM. Neonatal cholestasis is associated with cytochrome P450 1A2 detoxification defect: A single center pilot study. World J Clin Pediatr 2026; 15(1): 113478 [PMID: 41884039 DOI: 10.5409/wjcp.v15.i1.113478]

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