Efficacy and safety of dual-targeted therapy in children with inflammatory bowel disease: Retrospective cohort study

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Mar 9, 2026; 15(1): 111093
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.111093

Table 1 Inclusion and exclusion criteria of the study

Inclusion criteria	Exclusion criteria
Clinical or laboratory activity of IBD	Monogenic form of IBD requiring specific therapy (such as bone marrow transplantation, etс.)
Endoscopic activity
History of ineffectiveness or intolerance of tumor necrosis factor-alpha blockers as monotherapy or in combination with immunosuppressors, and at least one more biological drugs with a different mechanism

IBD: Inflammatory bowel disease.

Citation: Gabrusskaya T, Ulanova N, Shilova E, Volkova N, Kilina S, Kornienko E, Kostik M. Efficacy and safety of dual-targeted therapy in children with inflammatory bowel disease: Retrospective cohort study. World J Clin Pediatr 2026; 15(1): 111093
URL: https://www.wjgnet.com/2219-2808/full/v15/i1/111093.htm
DOI: https://dx.doi.org/10.5409/wjcp.v15.i1.111093

Gabrusskaya T, Ulanova N, Shilova E, Volkova N, Kilina S, Kornienko E, Kostik M. Efficacy and safety of dual-targeted therapy in children with inflammatory bowel disease: Retrospective cohort study. World J Clin Pediatr 2026; 15(1): 111093 [PMID: 41884046 DOI: 10.5409/wjcp.v15.i1.111093]

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