©Author(s) (or their employer(s)) 2026.
World J Clin Pediatr. Mar 9, 2026; 15(1): 111030
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.111030
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.111030
Figure 4 Pathophysiological mechanisms underlying metabolic dysfunction-associated steatotic liver disease and youth-onset type 2 diabetes in pediatric populations.
BCAA: Branched-chain amino acid; DAG: Diacylglycerol; IKK: IκB kinase; IL-6: Interleukin-6; IRS: Insulin receptor substrate; JNK: C-Jun N-terminal kinase; LPS: Lipopolysaccharide; MASLD: Metabolic dysfunction-associated steatotic liver disease; MDA: Malondialdehyde; mTOR: Mechanistic target of rapamycin; PK: Protein kinase; ROS: Reactive oxygen species; TNF-α: Tumor necrosis factor-alpha.
- Citation: Parizad R, Hatwal J, Brar AS, Alizadeh L, Goyal MK, Batta A, Mohan B. Interplay of childhood metabolic dysfunction-associated steatotic liver disease and obesity in the development of youth-onset type 2 diabetes. World J Clin Pediatr 2026; 15(1): 111030
- URL: https://www.wjgnet.com/2219-2808/full/v15/i1/111030.htm
- DOI: https://dx.doi.org/10.5409/wjcp.v15.i1.111030