Early inotropic support without fluid bolus vs standard resuscitation in pediatric septic shock: A randomized controlled trial

Table 5 Subgroup analysis of patients with compensated shock and hypotensive shock

Parameters	Patients with compensated shock (n = 16)				Patients with hypotensive shock (n = 33)
	Group I-1 (n = 8)	Group F-1 (n = 8)	P value	Group I-2 (n = 16)		Group F-2 (n = 17)	P value
Patients who had resolution of shock	8/8 (100)	8/8 (100)	1	16/16 (100)		11/17 (64.70)	0.018
Time of resolution of shock, minutes	80.63 (25.05)	125.63 (54.34)	0.052	85.66 (49.04)		110.23 (30.81), n = 11	0.154
VIS for resolution of shock	30.00 (13.09)	21.25 (9.90)	0.161	31.56 (15.02)		42.73 (32.59), n = 11	0.24
Mean fluid required within 6 h, mL/kg	0 (0), n = 0	27.50 (8.86)		28.00 (11.80), n = 5		31.76 (13.80)
Signs of fluid overload	0/8 (0)	4/8 (50.00)		1/16 (6.25)		12/17 (70.00)	0
Duration of inotropes, hours	68.00 (36.00-111.75)	70.50 (17.36-102.00)	0.574	113.52 (88.70)		37.82 (34.62)	0.003
Duration of ventilation, hours	109.00 (37.25-138.00), n = 4	50.00 (13.00-222.00), n = 5	0.556	76.00 (18.00-144.00), n = 11		22.50 (10.00-85.50), n = 14	0.222
Length of hospital stay, days	11.00 (4.06-20.00)	12.00 (7.25-22.50)	0.574	9.50 (3.88-23.50)		1.58 (0.89-15.00)	0.094
Maximum VIS during hospital stay	48.75 (36.82)	42.50 (37.70)	0.742	85.31 (48.35)		103.53 (70.71)	0.397
Mortality at 48 h	1/8 (12.50)	0/8 (0)		3/16 (18.75)		9/17 (52.94)	0.041
Discharge; death	4 (50.00); 4 (50.00)	6 (75.00); 2 (25.00)	0.608	8 (50.00); 8 (50.00)		7 (41.20); 10 (58.80)	0.732

VIS: Vasoactive inotropic support; Group I: Group receiving early inotropes without giving fluid bolus; Group F: Group receiving fluid resuscitation.