Early inotropic support without fluid bolus vs standard resuscitation in pediatric septic shock: A randomized controlled trial

doi:10.5409/wjcp.v15.i1.109864

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Clin Pediatr. Mar 9, 2026; 15(1): 109864
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.109864

Table 1 Baseline characteristics of the patients

	Group I (n = 24)	Group F (n = 25)	P value
	mean (± SD), median (IQR)	mean (± SD), median (IQR)	P value
Age, years	6.5 (1.0-11.0)	6.0 (1.13-11.0)	0.936
Sex, males	15 (62.5)	18 (72.0)	0.551
Duration of illness, days	6.5 (4.0-14.5)	5.0 (4.0-10.0)	0.402
Weight, kg	17.4 (12.1)	15.9 (9.8)	0.795
Height, cm	101.7 (40.7)	102.3 (29.7)	0.826
HR, per min	139 (27.6)	154 (30.8)	0.076
RR, per min	45 (19.4)	48 (20.9)	0.837
SBP	NR-3; 83.71 (16.9)	NR-6; 78.90 (14.7)	0.346
DBP	NR-3; 38.30 (12.4)	NR-7; 38.00 (15.4)	0.941
MAP	NR-3; 53.50 (11.1)	NR-7; 51.60 (13.6)	0.642
Systolic shock index = HR/SBP	n = 20; 1.8 (0.58)	n = 20; 1.8 (0.50)	0.599
Diastolic shock index = HR/DBP	n = 21; 3.976 (1.543)	n = 18; 4.612 (2.066)	0.278
IVC collapsibility index	31.70 (22.30-39.75)	34.00 (25.95-56.28)	0.190
Fever	19/24 (79.2)	20/25 (80.0)	1.000
GCS	14.50 (4.25-15.00)	13.00 (7.00-15.00)	0.916
Underlying comorbidity	12/24 (50.0)	11/25 (44.0)	0.778
Received prior intravenous antibiotics	13/24 (54.2)	10/25 (40.0)	0.396
Warm shock; cold shock	13/24 (54.2); 11/24 (45.8)	8/25 (32.0); 17/25 (68.0)	0.154
Compensated shock	8/24 (33.3)	8/25 (32.0)	1.000
Hypotensive shock	16/24 (66.7)	17/25 (68.0)	1.000
Hypoglycemia	3/24 (12.5)	2/25 (8.0)	0.667
Focus of infection			0.111
Blood stream	0/24 (0)	2/25 (8.0)
Respiratory	5/24 (20.8)	9/25 (36.0)
Abdomen	3/24 (12.5)	3/25 (12.0)
CNS	5/24 (20.8)	6/25 (24.0)
Joints/bones	2/24 (8.3)	0/25 (0)
Renal	0/24 (0)	3/25 (12.0)
Skin	4/24 (16.7)	1/25 (4.0)
Disseminated	5/24 (20.8)	1/25 (4.0)
pSOFA-L score	12.0 (3.9)	11.56 (3.7)	0.687

CNS: Central nervous system; DBP: Diastolic blood pressure; GCS: Glasgow Coma Scale; HR: Heart rate; IVC: Inferior vena cava; MAP: Mean arterial pressure; pSOFA-L score: Pediatric Sequential Organ Failure Assessment- Lactate score; RR: Respiratory rate; SBP: Systolic blood pressure; IQR: Interquartile range; Group I: Group receiving early inotropes without giving fluid bolus; Group F: Group receiving fluid resuscitation; NR-3: Not recordable (3 patients); NR-6: Not recordable (6 patients); NR-7: Not recordable (7 patients).

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Citation: Keshri S, Goel AK, Garg AK, Anand V, Rathia SK, Yusuf S. Early inotropic support without fluid bolus vs standard resuscitation in pediatric septic shock: A randomized controlled trial. World J Clin Pediatr 2026; 15(1): 109864
URL: https://www.wjgnet.com/2219-2808/full/v15/i1/109864.htm
DOI: https://dx.doi.org/10.5409/wjcp.v15.i1.109864

Keshri S, Goel AK, Garg AK, Anand V, Rathia SK, Yusuf S. Early inotropic support without fluid bolus vs standard resuscitation in pediatric septic shock: A randomized controlled trial. World J Clin Pediatr 2026; 15(1): 109864 [PMID: 41884053 DOI: 10.5409/wjcp.v15.i1.109864]

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