Diagnostic and prognostic utility of D-dimer and heparin-binding protein in neonatal sepsis: A prospective case-control study

Table 4 Univariate and multivariate logistic regression analysis for the independent parameters associated with sepsis

Parameter	Univariate		Multivariate
	OR (95%CI)	P value	OR (95%CI)	P value
Sepsis vs controls
CRP (mg/L)	1.25 (1.09-1.43)	0.001	1.20 (0.96-1.51)	0.11
HBP (ng/mL)	1.04 (1.02-1.06)	0.001	1.03 (1.00-1.05)	0.04
D-dimer (ng/mL)	1.09 (1.01-1.18)	0.03	1.15 (0.93-1.42)	0.05
WBCs (× 103/mm3)	1.38 (1.23-1.56)	< 0.0001	1.28 (0.99-1.65)	0.054
Neutrophils (%)	1.16 (1.11-1.24)	< 0.0001	1.00 (0.89-1.12)	0.99
Platelets (× 103/mm3)	0.43 (0.0-8.48 × 1052)	0.99	NI
Proven vs suspected sepsis
CRP (mg/L)	1.03 (1.00-1.06)	0.03	1.01 (0.97-1.06)	0.48
HBP (ng/mL)	1.00 (1.00-1.01)	0.007	1.007 (1.00-1.01)	0.04
D-dimer (ng/mL)	1.00 (1.00-1.00)	0.01	1.00 (1.00-1.00)	0.21
WBCs (× 103/mm3)	1.03 (0.94-1.13)	0.45	NI
Neutrophils (%)	1.02 (0.98-1.07)	0.26	NI
Platelets (× 103/mm3)	0.99 (0.95-1.03)	0.57	NI

CRP: C-reactive protein; HBP: Heparin binding protein; WBCs: White blood cells; NI: Not included.