Giant coronary aneurysms in children with Kawasaki disease and major cardiac complications and dynamic follow-up

Table 2 Clinical features of patients with Kawasaki disease and giant/medium coronary artery aneurysms

Parameters	Giant1 and medium2 CAA (n = 13)	Moderate CAA dilatation3 (n = 19)	P value
Onset age, years, median (25%, 75%)	2.0 (0.8, 5.0)	0.8 (0.4, 1.7)	0.196
Male sex	10 (77.0)	14 (74.0)	0.841
Number of days of fever, median (25%, 75%)	10 (5, 14)	5 (3, 10)	0.073
Complete Kawasaki disease criteria	7 (54.0)	6 (32.0)	0.220
Neurological symptoms	8 (62.0)	4 (21.0)	0.019
Aseptic meningitis	2 (15.0)	2 (11.0)	0.694
Acute kidney failure	1 (8.0)	2 (11.0)	0.795
Polyserositis	2 (15.0)	2 (11.0)	0.694
Hematologic abnormalities	1 (8.0)	1 (5.0)	0.788
Coronary thrombosis	5 (42.0)	1 (5.0)	0.017
Shock	7 (54.0)	4 (21.0)	0.057
Acute heart failure	2 (17.0)	1 (5.0)	0.350
Myocardial dysfunction (heart failure) 1-4 functional class	10 (77.0)	11 (58.0)	0.280
Pericarditis	5 (38.0)	6 (32.0)	0.698
Hemophagocytic syndrome	1 (8.0)	2 (11.0)	0.795
Left ventricle dilatation	1 (8.0)	2 (11.0)	0.795
Right ventricle dilatation	3 (23.0)	3 (16.0)	0.617
Reduced left ventricle ejection fraction	1 (8.0)	0 (0)	-

¹Giant coronary artery aneurysm (CAA) was defined by a Z-score > 10 standard deviations (SD).

²Medium CAA was defined by a Z-score > 5 SD but < 10 SD.

³Moderate CAA dilatation was defined by Z-score < 5 SD but > 2.5 SD.

CAA: Coronary artery aneurysms.