Juvenile arthritis damage index predicts poor response to biological treatment: A prospective cohort study

Table 1 The predictors of damage in patients with juvenile idiopathic arthritis

Parameter	Se	Sp	OR (95%CI)	RR (95%CI)	P value
Polyarthricular JIA category	35.0	86.5	3.5 (1.3-9.0)	1.6 (1.2-2.2)	0.017
ANA positivity	45.0	75.0	2.5 (1.1-5.5)	1.5 (1.1-2.1)	0.027
Arthritis of ≥ 5 joints at onset	25.0	90.4	3.1 (1.1-9.3)	1.5 (1.1-2.1)	0.034
Active joints > 8 at the study inclusion	55.0	76.9	4.1 (1.8-9.3)	1.8 (1.3-2.6)	< 0.001
Parental/patient VAS > 6 cm	53.3	71.2	2.8 (1.3-6.2)	3.2 (1.6-6.2)	0.009
MDVAS > 6 cm	88.3	50.0	7.6 (2.9-19.7)	3.2 (1.6-6.2)	< 0.001
JADAS71 > 17.7 points	81.7	48.1	4.1 (1.8-9.7)	2.1 (1.3-3.6)	0.001
CHAQ > 0 points	68.3	59.6	3.2 (1.5-6.9)	1.7 (1.2-2.6)	0.003
Ankylosis, confirmed by X-ray	29.8	97.9	19.5 (2.4-155.8)	2.2 (1.7-3.0)	0.008
MRI-confirmed erosions	49.0	90.9	12.5 (3.8-40.9)	2.2 (1.6-3.1)	< 0.001

Se: Sensitivity; Sp: Specificity; CI: Confidence interval; OR: Odds ratio; RR: Relative risk; JIA: Juvenile idiopathic arthritis; ANA: Antinuclear antibody; VAS: Visual-analogue scale; MDVAS: Physician’s visual-analogue scale; JADAS: Juvenile arthritis disease activity score; CHAQ: Childhood Health Assessment Questionnaire; MRI: Magnetic resonance imaging.