Comprehensive study of community acquired Mycoplasma pneumoniae pneumonia in children in Baoding, China, 2023

Table 3 Serum cytokine levels in children (2–13 years) with Mycoplasma pneumoniae pneumonia, median (interquartile range)

Cytokines (pg/mL)	SMPP cases (n = 73)	GMPP cases (n = 103)	P value
Children 2-5 years old (SMPP 12 cases vs GMPP 23 cases)
IL-1β	1.18 (1.03, 1.27)	1.16 (0.81, 1.55)	0.897
IL-2	0.43 (0.12, 0.66)	0.77 (0.05, 1.04)	0.340
IL-4	0.92 (0.78, 1.37)	1.05 (0.81, 1.31)	0.715
IL-5	1.31 (0.51, 2.01)	1.58 (1.21, 2.09)	0.175
IL-6	52.62 (6.32, 69.84)	36.75(16.98, 64.12)	0.889
IL-8	11.25 (2.08, 76.07)	15.76 (9.37, 27.94)	0.424
IL-10	5.45 (3.65, 11.83)	2.53 (1.60, 4.55)	0.056
IL-12p70	0.09 (0.00, 0.30)	0.15 (0.07, 0.26)	0.207
IL-17A	1.17 (0.91, 1.28)	1.06 (0.91, 1.39)	0.626
IL-17F	1.31 (1.01, 2.20)	0.95 (0.91, 1.09)	0.003
IL-22	1.64 (1.34, 2.94)	1.48 (1.15, 2.11)	0.520
IFN-γ	9.56 (4.19, 15.16)	5.81 (3.38, 22.22)	0.677
TNF-α	1.14 (0.25, 1.93)	0.57 (0.00, 1.65)	0.575
TNF-β	0.17(0.00, 0.71)	0.00 (0.00, 0.30)	0.140
Children 6-13 years old (SMPP 61 cases vs GMPP 80 cases)
IL-1β	1.26 (0.87, 2.10)	1.20 (0.99, 1.51)	0.496
IL-2	0.77 (0.18, 1.47)	0.82 (0.27, 1.30)	0.784
IL-4	0.99 (0.74, 1.61)	1.12 (0.90, 1.32)	0.474
IL-5	1.45 (1.08, 2.59)	1.73 (1.26, 2.32)	0.500
IL-6	50.00 (17.60, 174.22)	24.56 (11.09, 65.74)	0.056
IL-8	17.09 (8.81, 39.10)	12.20 (7.63, 81.44)	0.752
IL-10	3.69 (2.00, 8.62)	2.24 (1.56, 3.66)	0.003
IL-12p70	0.27 (0.12, 0.53)	0.26 (0.05, 0.40)	0.217
IL-17A	1.02 (0.81, 1.49)	1.08 (0.85, 1.41)	0.585
IL-17F	1.05 (0.92, 2.11)	1.12 (0.93, 1.56)	0.932
IL-22	1.80 (1.12, 3.52)	1.79 (1.24, 3.24)	0.917
IFN-γ	8.73 (3.11, 16.77)	4.69 (3.49, 9.78)	0.046
TNF-α	1.92 (0.64, 4.59)	0.98 (0.07, 1.89)	0.007
TNF-β	0.15 (0.00, 1.04)	0.06 (0.00, 0.74)	0.797

IFN: Interferon; IL: Interleukin; GMPP: General Mycoplasma pneumoniae pneumonia; SMPP: Severe Mycoplasma pneumoniae pneumonia; TNF: Tumor necrosis factor.