Comprehensive study of community acquired Mycoplasma pneumoniae pneumonia in children in Baoding, China, 2023

Table 1 Routine hematological and biochemical parameters in blood samples from children (2–13 years) with Mycoplasma pneumoniae pneumonia, median (interquartile range)

Laboratory parameters	SMPP cases (n = 245)	GMPP cases (n = 852)	P value
Children 2–5 years old (SMPP 49 cases vs GMPP 164 cases)
Leukocytes (109/L)	7.83 (6.37, 9.26)	8.11 (6.24, 9.82)	0.792
Neutrophils (%)	62.1 (52.7, 67.7)	56.7 (48.3, 64.2)	0.039
Lymphocytes (%)	28.1 (24.2, 37.6)	32.8 (25.8, 40.7)	0.073
Eosinophils (%)	0.6 (0.3, 2.8)	1.2 (0.4, 2.8)	0.248
Platelet count (109/L)	279 (218, 353)	299 (238, 377)	0.197
C-reactive protein (mg/L)	11.77 (4.68, 26.47)	7.846 (2.63, 17.21)	0.041
ALT (U/L)	15 (10, 28)	12 (10, 21)	0.072
AST (U/L)	32 (26, 42)	29 (24, 36)	0.066
CK (U/L)	56 (36, 127)	65 (45, 89)	0.956
CKMB (ng/mL)	2.92 (2.05, 3.65)	2.60 (2.03, 3.19)	0.233
LDH (U/L)	354 (294, 477)	288(256, 343)	< 0.001
Procalcitonin (ng/mL)	0.23 (0.10, 0.51)	0.12 (0.08, 0.26)	< 0.001
ESR (mm/h)	26 (17, 45)	30 (20, 50)	0.262
Prothrombin time (s)	12.5 (11.7, 13.0)	12.2 (11.6, 13.0)	0.47
INR	1.12 (1.05, 1.16)	1.11 (1.04, 1.17)	0.984
aPTT (s)	31.5 (28.9, 34.5)	33.0(30.4, 35.5)	0.088
Fibrinogen (g/L)	3.40 (3.16, 3.86)	3.68 (3.28, 4.10)	0.075
FDPs (mg/L)	2.2 (1.3, 4.1)	1.4 (0.9, 2.3)	0.008
D-dimer (mg/L)	0.389 (0.211, 0.711)	0.215 (0.142, 0.389)	< 0.001
Plasma antithrombin III (%)	110 (96, 119)	113 (103, 120)	0.271
Children 6–13 years old (SMPP 196 cases vs GMPP 688 cases)
Leukocytes (109/L)	8.47 (6.54, 10.92)	7.96 (6.28, 9.88)	0.022
Neutrophils (%)	68.1 (60.1, 76.4)	61.8 (53.5, 69.0)	< 0.001
Lymphocytes (%)	21.4 (15.9, 29.2)	27.7 (21.3, 34.9)	< 0.001
Eosinophils (%)	0.8 (0.2, 2.3)	1.1 (0.4, 2.8)	0.034
Platelet count (109/L)	272 (218, 335)	281 (231, 359)	0.056
C-reactive protein (mg/L)	18.59 (9.40, 40.09)	9.19 (3.47, 19.32)	< 0.001
ALT (U/L)	19 (13, 31)	14 (11, 22)	< 0.001
AST (U/L)	30 (20, 47)	25 (20, 30)	< 0.001
CK (U/L)	70 (43, 138)	66 (46, 97)	0.180
CKMB (ng/mL)	2.38 (1.81, 3.13)	2.33 (1.85, 3.03)	0.830
LDH (U/L)	321 (255, 439)	265 (232, 309)	< 0.001
Procalcitonin (ng/mL)	0.15 (0.09, 0.33)	0.10 (0.06, 0.16)	< 0.001
ESR (mm/h)	32 (20, 50)	33 (20, 50)	0.910
Prothrombin time (s)	13.1 (12.3, 14.0)	12.6 (12.0, 13.4)	< 0.001
INR	1.18 (1.11, 1.26)	1.14 (1.09, 1.21)	< 0.001
aPTT (s)	31.8 (29.3, 34.1)	32.7 (30.7, 35.1)	< 0.001
Fibrinogen (g/L)	4.00 (3.45, 4.61)	3.93 (3.53, 4.35)	0.137
FDPs (mg/L)	3.2 (1.7, 6.4)	1.5 (1.0, 2.5)	< 0.001
D-dimer (mg/L)	0.512 (0.226, 1.114)	0.236 (0.150, 0.376)	< 0.001
Plasma antithrombin III (%)	103 (96, 111)	106 (98, 114)	0.022

ALT: Alanine aminotransferase; aPTT: Activated partial thromboplastin time; AST: Aspartate transaminase; CK: Creatine kinase; CKMB: Creatine kinase-MB; ESR: Erythrocyte sedimentation rate; GMPP: General Mycoplasma pneumoniae pneumonia; INR: International standardized ratio; LDH: Lactate dehydrogenase; SMPP: Severe Mycoplasma pneumoniae pneumonia; FDPs: Fibrin and fibrinogen degradation products.