Determinants of infection for antibiotic initiation at pediatric emergency admission: A prospective observational study

Table 4 Binomial logistic regression for the predictors of bacterial infection

Variables	Univariate analysis		Multivariable analysis
	Crude odds ratio (95%CI)	P value	Adjusted odds ratio (95%CI)	P value
Color
Normal	1		1
Abnormal	4.074 (2.195-7.561)	< 0.001	2.362 (0.814-6.849)	0.114
Initial physiological changes
Stable	1		1
Non-threatening	1.576 (0.578-4.297)	0.374	1.478 (0.386-5.655)	0.568
Life-threatening	3.965 (1.489-10.556)	0.006	1.402 (0.333-5.896)	0.645
Fever
Absent	1		1
Present	2.382 (1.332-4.258)	0.003	2.388 (1.020-5.595)	0.045
Features of capillary leak
Absent	1		1
Present	5.210 (2.297-11.816)	< 0.001	5.929 (1.740-20.208)	0.004
Altered sensorium
Absent	1	0.001	1	0.007
Present	4.094 (1.825-9.183)		4.569 (1.501-13.907)
Oliguria
Absent	1	0.026	1	0.764
Present	4.808 (1.205-19.190)		1.350 (0.191-9.565)
Pallor
Absent	1	< 0.001	1	0.085
Present	4.386 (2.278-8.444)		2.453 (0.883-6.814)
Organomegaly
Absent	1	0.002	1	0.432
Present	2.704 (1.432-5.107)		0.672 (0.249-1.812)
Rash
Absent	1	0.022	1	0.304
Present	3.769 (1.214-11.702)		2.778 (0.395-19.522)
Cellulitis
Absent	1	0.013	1	0.1
Present	14.636 (1.764-121.417)		11.557 (0.623-214.319)
Immunodeficiency
No	1	0.002	1	0.151
Yes	4.803 (1.742-13.242)		2.641 (0.701-9.946)
Prior antibiotic use
No	1	< 0.001	1	0.006
Yes	5.512 (2.567-11.837)		4.312 (1.515-12.268)
CRP	1.004 (1.002-1.005)	< 0.001	1.003 (1.001-1.005)	0.001
ANC	1.000 (1.000-1.000)	0.021	1.000 (1.000-1.000)	0.237

CRP: C-reactive protein; ANC: Absolute neutrophil count; CI: Confidence interval.