Determinants of infection for antibiotic initiation at pediatric emergency admission: A prospective observational study

Table 3 Diagnostic characteristics of different variables associated with a bacterial infection

Variable	Cutoff	AUC (95%CI)	Sensitivity	Specificity	PPV	NPV	LR+	LR-	Accuracy
CRP (mg/dL)	60	0.71 (0.63-0.79)	68.49	68.34	53.19	80.51	2.16	0.46	68.39
TLC (per mm3)	14170	0.55 (0.49-0.62)	51.15	66.95	36.81	78.45	1.55	0.73	62.63
ANC (per µL)	8800	0.59 (0.53-0.65)	47.33	72.99	39.74	78.64	1.75	0.72	65.97
ESR (mm/hour)	42	0.73 (0.59-0.88)	80.00	74.07	74.07	80.00	3.09	0.27	76.92
Procalcitonin (ng/mL)	0.72	0.74 (0.65-0.83)	70.37	75.31	65.52	79.22	2.85	0.39	73.33
Albumin (g/dL)	3.70	0.80 (0.75-0.85)	78.41	70.09	85.54	58.99	2.62	0.31	75.85
Lactate (mmol/L)	1.75	0.50 (0.43-0.57)	43.89	65.51	76.38	31.49	1.27	0.86	50.00

AUC: Area under the curve; ESR: Erythrocyte sedimentation rate; TLC: Total leukocyte count; CRP: C-reactive protein; ANC: Absolute neutrophil count; PPV: Positive predictive value; NPV: Negative predictive value; CI: Confidence interval; LR: Likelihood ratio.