MicroRNA-320а as a novel biomarker at preclinical stage of necrotizing enterocolitis in term neonates with congenital heart defects

Figure 1 Diagnostic potential of the studied microRNAs in the plasma samples of term newborns with critical congenital heart defects in distinguishing the risk of necrotizing enterocolitis development. A: The relative expression levels of target microRNAs (miRs); B: Receiver operator characteristic (ROC) curve for each target miR in the preoperative period; C: ROC curve of each target miRs in the postoperative period; D: ROC curve of the combined three miRs (miR-155 + miR-223 + miR-320a) vs miR-320a alone for predicting necrotizing enterocolitis (NEC) development before clinical symptoms; E: ROC analysis statistics for the studied miRs during the perioperative period. No-NEC_BS and No-NEC_AS represent no-NEC newborns before and after cardiac surgery, NEC_BS and NEC_AS represent NEC newborns before and after cardiac surgery, respectively. AUC: Area under the curve; MiRs: MicroRNAs; NEC: Necrotizing enterocolitis.