MicroRNA-320а as a novel biomarker at preclinical stage of necrotizing enterocolitis in term neonates with congenital heart defects

Table 4 Kyoto encyclopedia of genes and genomes and gene ontology pathways regulated by the differentially expressed microRNAs

MiRs	Term name	Term genes (n)	P value	False discovery rate	Target genes
Kyoto Encyclopedia of Genes and Genomes (pathways union)
MiR-155-5p miR-223-3p, miR-320a-3p	Forkhead box O signaling pathway	139	7.31e-10	1.66e-8	18 by miR-155-5p, 6 by miR-223-3p, 20 by miR-320a-3p
	Prostate cancer	101	5.77e-8	7.84e-7	15 by miR-155-5p, 4 by miR-223-3p, 15 by miR-320a-3p
MiR-155-5p, miR-320a-3p	Hippo signaling pathway	164	1.20e-10	4.07e-9	21 by miR-155-5p, 31 by miR-320a-3p
	Viral carcinogenesis	265	1.07e-10	4.07e-9	29 by miR-155-5p, 42 by miR-320a-3p
	Pathways in cancer	555	8.83e-9	1.50e-7	53 by miR-155-5p, 60 by miR-320a-3p
	Transcriptional misregulation in cancer	206	1.13e-7	1.28e-6	21 by miR-155-5p, 32 by miR-320a-3p
	Colorectal cancer	88	3.43e-7	3.33e-6	15 by miR-155-5p, 15 by miR-320a-3p
	Chronic myeloid leukemia	79	5.08e-6	2.88e-5	12 by miR-155-5p, 14 by miR-320a-3p
	Hepatitis B	177	8.83e-6	4.62e-5	22 by miR-155-5p, 21 by miR-320a-3p
	Protein processing in endoplasmic reticulum	194	2.04e-4	4.91e-4	20 by miR-155-5p, 22 by miR-320a-3p
MiR-223-3p, miR-320a-3p	Signaling pathways regulating pluripotency of stem cells	156	1.67e-6	1.26e-5	5 by miR-223-3p, 22 by miR-320a-3p
	Longevity regulating pathway	105	5.56e-5	1.89e-4	4 by miR-223-3p, 14 by miR-320a-3p
Gene Ontology (genes intersection)
MiR-155-5p, miR-223-3p, miR-320a-3p	Cytokine-mediated signaling pathway	319	2.93e-3	2.63e-2	2 by miR-155-5p, 2 by miR-223-3p, 2 by miR-320a-3p

MiRs: MicroRNAs.