MicroRNA-320а as a novel biomarker at preclinical stage of necrotizing enterocolitis in term neonates with congenital heart defects

Table 1 Distribution of congenital heart defects in the study cohort, n (%)

Type of congenital heart defect	Total	No-NEC	NEC	Type of cardiac surgery
				No-NEC (n)	NEC (n)
Single-ventricle CHD
Hypoplastic left heart syndrome	2	1 (4)	1 (4)	Damus-Kaye-Stansel procedure (1)	Norwood procedure (1)1
Double-inlet left ventricle + Pulmonary artery/CoAo	2	1 (4)	1 (4)	MBTS placement (1)	Norwood procedure (1)
Unbalanced (right ventricle dominant) atrioventricular septal defect + CoAo	1	1 (4)	0	Modified Amato technique (1)	0
Total	5	3 (13)	2 (9)
Two-ventricle CHD
Transposition of the great arteries	7	5 (22)	2 (9)	ASO (4). ASO + Modified Amato technique (1)	ASO (1). MBTS placement (in left ventricular outflow tract obstruction) (1)2
Coarctation of the aorta	5	3 (13)	2 (9)	Modified Amato technique (2). End-to-end anastomosis (1)	Modified Amato technique (1). End-to-end anastomosis (1)
Pulmonary atresia/stenosis	4	2 (9)	2 (9)	mBTS placement (1). Antegrade palliation (1)	MBTS placement (2)
Aortic valve stenosis	2	1 (4)	1 (4)	Aortic commissurotomy (1)	Aortic commissurotomy (1)
Total	18	11 (48)	7 (30)

¹Mortality related to acute heart failure in congenital heart defects (CHD).

²Mortality related to acute heart failure in CHD and necrotizing enterocolitis.

ASO: Arterial switch operation; CHD: Congenital heart defects; CoAo: Coarctation of the aorta; MBTS: Modified Blalock-Taussig shunt; NEC: Necrotizing enterocolitis