Prematurity is a risk factor of disorders of gut-brain interaction in adults: A case-control study

Table 4 Prevalence of disorders of gut-brain interaction according to sex, n (%)

	Cases		Controls		P value
Sex	M	F	M	F	M	F
Number	24	55	60	64
Age	27 (24; 30)	27 (24; 29)	41 (29; 55)	29 (25; 44)	< 0.001	< 0.001
Range	18-32	21-32	22-75	20-75
A: Esophageal disorders	0	5 (9%)	4 (7%)	8 (13%)	0.47	0.76
B: Gastroduodenal disorders	3 (13%)	20 (36%)	11 (18%)	10 (16%)	0.75	0.02
B1a: Postprandial distress syndrome	3 (13%)	7 (13%)	5 (8%)	3 (5%)	0.86	0.21
B1b: Epigastric pain Syndrome	0	6 (11%)	2 (3%)	4 (6%)	0.91	0.56
C: Bowel disorders	5 (21%)	35 (64%)	14 (23%)	26 (41%)	1	0.02
C1: Irritable bowel syndrome	1	11	1	10	1	0.7
C2: Functional constipation	4	16	3	7	0.19	0.02
C3: Functional diarrhea	0	7	2	5	0.9	0.56
D: Centrally mediated disorders of gastrointestinal pain	0	0	0	0	N/A	N/A
E: Gallbladder and sphincter of Oddi disorders	0	0	0	1 (2%)	N/A	1
F: Anorectal disorders	0	3 (6%)	3 (5%)	9 (14%)	0.64	0.21
At least 1 pain-related DGBI1	1 (4%)	14 (26%)	7 (12%)	17 (27%)	0.52	1

¹Pain related disorders of gut-brain interaction are defined as functional chest pain, functional heartburn, reflux hypersensitivity, epigastric pain syndrome, irritable bowel syndrome, abdominal pain subclass of unspecified functional bowel disorder, centrally mediated abdominal pain syndrome, biliary pain, levator ani syndrome, unspecified functional anorectal pain and proctalgia fugax.

DGBI: Disorders of gut-brain interaction; F: Female; M: Male; N/A: Not applicable.